New Frontier Labs: Medical Uses of Brown Recluse

tHE hISTORY OF maims

New Wine in Old Bottles

Humankind has uncomprehendingly been using MAIMS for millennia. Olive oil for instance has been in human use at least since the end of the Stone Age. Ethanol, produced by the fermentation of various carbohydrates such as grapes to make wine and corn to make whiskey is also a MAIM.

MAIMS in Recent Times

In the 19th century Modern Medicine was aborning. General anesthesia, antisepsis, X-rays for medical imaging, aspirin and the use of quinine for the treatment of malaria were all discovered and developed.

Our BUSINESS

Our Product is Intellectual Property

Indication Patent No. License Status

Insulin resistance US 10,251,857 B2 Available

Type 2 Diabetes US 11,026,912 B2 Available

Dyslipidemia US App. No. 62/978,785 Available

Brown Recluse Bite / PLD US 11,918,555 Available

Musculoskeletal Pain US 11,911,358 Available

Next Generation Insulin Resistance US App No. 18/806,476 Available

Next Generation Pain Reliever US App No. 18/806,476 Available

Our Goal

We are researchers. We seek to out-license the fruits of our studies for further development and commercialization. All of the above indications have been proven in human studies. Contact us for more details. .

SCIENTIFIC pUBLICATIONS And Patents

Peer Reviewed Publications

Streeper RT, Louden C, Izbicka E Oral Azelaic Acid Ester Decreases Markers of Insulin

Resistance in Overweight Human Male Subjects. in vivo 34:1173-1186 (2020)

https://doi.org/10.21873/invivo.11890

Izbicka E, Streeper RT, Louden C Adaptive Membrane Fluidity Modulation: A Feedback Regulated Homeostatic System and Target for Pharmacological Intervention. in vivo 35: 3073-3095 (2021)

https://doi.org/10.21873/invivo.12603

Izbicka E, Streeper RT Adaptive Membrane Fluidity Modulation: A Feedback Regulated Homeostatic System Hiding in Plain Sight. in vivo 35: 2991-3000 (2021)

https://doi.org/10.21873/invivo.12594

Izbicka E, Streeper RT Azelaic Acid Esters as Pluripotent Immunomodulatory

Molecules: Nutritional Supplements or Drugs. Nutraceuticals 2021, 1:42-53 (2021)

https://doi.org/10.3390/nutraceuticals1010006

Streeper RT, Izbicka E Diethyl Azelate for the Treatment of Brown Recluse

Spider Bite, a Neglected Orphan Indication. in vivo 36:86-93 (2022)

https://doi.org/10.21873/invivo.12679

Izbicka E, Streeper RT, Louden C Membrane Active Immunomodulator As a Novel Therapy

for an Infectious Bacterial Disease, Buruli Ulcer. In Vivo 36: 2615-2629 (2022)

https://doi.org/10.21873/invivo.12996

Izbicka E, Streeper RT 2023 Mitigation of Insulin Resistance by Natural Products from a New Class of Molecules, Membrane-Active Immunomodulators. Pharmaceuticals 16:913 (2023)

https://doi.org/10.3390/ph16070913

Izbicka E, Streeper RT (2023) Cancer drug development yesterday, today and tomorrow https://medicalxpress.com/news/2023-08-editorial-cancer- drug-yesterday-today.html

https://doi.org/10.18632/oncoscience.583ist.

Diethyl Azelate for the Treatment of Brown Recluse

Spider Bite, a Neglected Orphan Indication: A Commentary

J Dermatol & Skin Sci. 2024;6(2):4-8

Granted United States Patents

AZELAIC ACID ESTERS IN THE TREATMENT OF INSULIN RESISTANCE US 10,251,857 B2 (April 9, 2019)

AZELAIC ACID ESTERS IN THE TREATMENT OF INSULIN RESISTANCE US 11,026,912 B2 (June 8, 2021)

DICARBOXYLIC ACID ESTERS FOR INDUCING AN ANALGESIC EFFECT US 11,911,358 (February 27, 2024)

DICARBOXYLIC ACID ESTERS FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH PHOSPHOLIPASE D TOXIN US 11,918,555 (March 5, 2024)

Pending United States Patents

AZELAIC ACID ESTERS IN THE TREATMENT OR PREVENTION OF DYSLIPIDEMIA AND ASSOCIATED CONDITIONS https://patents.justia.com/patent/20210251939

COMPOSITIONS AND METHODS FOR ENHANCING THE EFFICACY OF DICARBOXYLIC ACID ESTERS, AND USES THEREOF U.S. Patent Application No. 18/806,476

Granted International Patents

Patents based on US 10,251,857 (Expiry 2037)

1. New Zealand Patent number 746669

2. Greece Patent number 3110983

3. Slovakia Patent number 3445354

4. Slovenia Patent number 3445354

5. Romania Patent number 3445354

6. Portugal Patent number 3445354

7. Poland Patent number 3445354

8. Norway Patent number 3445354

9. Netherlands Patent number 3445354

10. Malta Patent number 3445354

11. Monaco Patent number 3445354

12. Latvia Patent number 3445354

13. Luxembourg Patent number 3445354

14. Lithuania Patent number 3445354

15. Iceland Patent number 3445354

16. Ireland Patent number 3445354

17. Hungary Patent number 3445354

18. Croatia Patent number 3445354

19. Great Britain Patent number 3445354

20. France Patent number 3445354

21. Finland Patent number 3445354

22. Estonia Patent number 3445354

23. Denmark Patent number 3445354

24. Czechia Patent number 3445354

25. Cyprus Patent number 3445354

26. Switzerland Patent number 3445354

27. Bulgaria Patent number 3445354

28. Belgium Patent number 3445354

29. Austria Patent number 3445354

30. North Macedonia Patent number P-2022/427

31. Sweden Patent number 17786579.7

32. Spain Patent number 17786579.7

33. Australia Patent number 2017253088

34. Serbia Patent number P-2022/0773

35. Singapore Patent number 11201808367U

36. Albania Patent number AL-P-2022-443

37. San Marino Patent number SM-T-202200351

38. Türkiye Patent number TR2022013181T4

39. China Patent number 201780024922.8

40. Germany Patent number 602017057846.0

41. Italy Patent number 502022000053982

.

My Brown Recluse Bites

I am Rob Streeper and this is the story of my brown recluse spider bites.

The first bite happened in the spring of 2016. I was working on the siding of our house. I was up on a ladder and I brushed my right arm against my ribs and I felt a sting. I looked down and there was a light brown spider crawiing down my arm. I quickly smacked it and finished my work. Later in the day I was sitting in front of my computer and I idly scratched my right forearm. I felt wetness, looked down and saw that